Synthesis, Characterization and In Vitro Antibacterial Evaluation of Sn, Sb, and Zn Coordination Complexes of 2-(2-Methoxyphenyl)-1H-Isoindole-1, 3(2h)-Dione

摘要

Hunting of new biologically active compounds is the need of time. Thanks to metals for being the charm of this field since more than half a century. Present report describes the synthesis, chemistry and biological evaluation of metal complexes of N-aryl phthalimides, a very interesting class of compounds in terms of their wide biological and chemical applications. Ortho anisidine is reacted with phthalic anhydride under solvent free condition to give N-substituted aryl phthalimide (Ligand A). The resultant phthalimide is then reacted with different metals like alkyl Tin (IV) halides, Antimony (III), and Zinc (II) to form novel coordination complexes (C1-C7). All the synthesized compounds have been characterized by 1H NMR, 13C NMR, 119Sn NMR, FTIR, Mass spectrometry for m/z ratio. Fascinatingly, the synthesized complexes have shown improved antibacterial effects in comparison to their parent ligands against standard Ciprofloxacin.