Besides many other activities the necessity of investigation of antiulcer as well as antioxidant activity from natural origin has also been increased due to having certain side effects, adverse effects, drug interaction of allopathic drugs. The main objective of the present study includes investigation of antiulcer and antioxidant activities of 60 % ethanolic leaves extract of Carissa carandas Linn. Antiulcer activity was investigated using ethanolic acid induced gastric ulcer model. Carissa carandas Linn. Showed protection index of 42.45%, 47.17 % and 64.15 % at the dose of 100, 200 and 400 mg/kg respectively while standard drug omeprazole also showed a protection index of 73.59 % which were statistically more significant. The antioxidant activity was investigated using DPPH free radical scavenging assay. The IC50 values of extract as well as ascorbic acid were 15.01 μg/ml as well as 3.56 μg/ml respectively. Further studies can be carried out for identification and isolation of compounds of Carissa carandas Linn. which are responsilble for such activities.
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