Screening of Leaf Extracts of Azadirachta Indica (Neem), Aegle Marmelos (Bael) and Trigonella Foenum Graecum (Methi) for their Inhibitory Activity on the Strains of Pseudomonas Aeruginosa, Staphylococcus Aureus and Candida SPP.”

摘要

Analytical tests for identification, purity and assay of active molecule citalopram – racemic mixture and enantiomer in substance as well as in drug preparations were developed. The methods were optimized on the base of validation procedures in accordance with European Pharmacopoeia, EMA and ICH. Tests are HPLC with using of chiral chromatography column and they are distinguished with excellent reproducibility, accuracy, high sensitivity and stereo selectivity Using developed methods the kinetic profile of chemical stability of citalopram in biological media and ratio of enantiomers were determined depending on kind of solvent mixture, pH and time.