Multidrug drug-resistant bacteria are becoming increasingly problematic predominantly in under developed countries. Methicillin-resistant Staphylococcus aureus (MRSA), Penicillin-resistant Streptococcus pneumonia and Vancomycin-resistant Enterococcus faecium are the major microorganisms that have seen to be a geometric rise in numbers. In order to overcome the increasing risk of drug-resistant strains of the human pathogen, there is a need in developing new antibiotics, these can be sourced from nature itself. Fungal endophytes are useful resources for active compounds that have a wide range of medical, agricultural and industrial application. Screening the antimicrobial compounds from endophytes is an auspicious way to meet the increasing threat of drug-resistant strains of clinical pathogens. This review article presents some data related to this problem.
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