ANTICANCER ACTIVITY OF CALOPHYLLUM INOPHYLLUM L., ETHANOLIC LEAF EXTRACT IN MCF HUMAN BREAST CELL LINES

摘要

Cancer is a major health problem; almost thought – out the world. Herbal medicines have a vital role in the prevention and treatment of cancer. The present study, the in vitro anticancer activity of Calophyllum inophyllum ethanolic leaf extract was evaluated in MCF-7 Breast cancer cell lines. Anticancer activity was evaluated with MTT standard colorimetric assay against MCF-7 cells with IC50 value of 120μg/mL. The biologically active metabolites were identified and quantified by a GC-MS method shows presence of 11 different bioactive compounds. The cytotoxic effect was found to be concentration dependent. Increased concentration of the leaf extract showed increased cytotoxicity