Development and Validation of StabilityIndicating HPLC Assay Method for Determination of Mesalamine in Bulk Drug andTablet Formulation” lang='EN-IN' style='font-size:12.0pt;font-family:'Calibri','sans-serif';mso-fareast-font-family:'Times New Roman';mso-ansi-language:EN-IN;mso-fareast-language:EN-US;mso-bidi-language:AR-SA;mso-bidi-font-weight

摘要

The review relates to advancements in development of orodispersible tablet formulation to present an impact on drug candidate’s characteristics for improvement in bioavailability. The purpose of the article is to review potential advancements of ODT technology in drug delivery applications. Various techniques employed to prepare ODTs include direct compression method, freeze drying, spray drying, tablet moulding, sublimation and mass extrusion. ODTs could be preferred choice especially with those drugs sensitive to GI and for patients under category of paediatrics, geriatrics, bedridden, postoperative and who may have difficulty in swallowing the conventional tablets and capsules. Orally disintegrating tablet (ODTs) are solid dosage form that involves the rapid disintegration and dissolution of dosage form presenting as solution or suspension state when placed in the mouth. ODTs render enhanced acceptability due to its patient compliance as well as improved bioavailability and stability. This article reviews recent trends undertaken to develop ODTs, new ODTs technologies, suitability of drug candidate and characterisation of ODTs.