EVALUATION OF THE ANTICONVULSANT ACTIVITY OF ETHANOL EXTRACT OF PSIDIUM GUAJAVA (GUAVA LEAVES) IN ALBINO MICE

摘要

ABSTRACT : Objective: To evaluate the anticonvulsant activity of ethanolic extract (200mg/kg & 400mg/kg) of Psidium guajava (guava leaves) in albino mice. Methods: Albino mice (25-30gms) of either sex were randomly selected and divided into 4 groups of 6 mice each, Group I (control) – Distilled water (vehicle) 1ml, Group II (Standard) – Valproic acid (40mg/kg), Group III – T1, Ethanolic extract of Psidium guajava (200mg/kg), Group IV- T2, Ethanolic extract of Psidium guajava (400mg/kg). All drugs were administered orally 1 hr prior to induction of seizures. The anticonvulsant activity was screened using maximal electroshock (MES) and pentylenetetrazole (PTZ) models. Results: The data was analysed by one way ANOVA followed by Bonferonni’s multiple comparison test. Ethanolic extract of Psidium guajava dose dependently produces significant antiepileptic activity in comparison to control. In MES test, the percentage inhibition of seizure is T2 -49 % and T1 – 37% in comparison to control. In PTZ test the percentage protection from seizure by T2 is 83.4% and T1 is 50% when compared to standard drug. Conclusion: Ethanolic extract of Psidium guavajava leaves showed significant anticonvulsant activity. Higher dose (400mg/kg) of ethanolic extract showed better antiepileptic activity when compared to lower dose (200mg/kg).