ANTI-HYPERGLYCEMIC AND ANTIOXIDANT ACTION OF AZADIRACHTA INDICA LEAF IN ALLOXAN INDUCED TYPE-I DIABETES MELLITUS IN EXPERIMENTAL DIABETIC SWISS ALBINO MICE: A HISTOPATHOLOGICAL INVESTIGATION

摘要

Objective: To attenuates hyperglycemia-mediated oxidative stress and protects liver marker enzymes in Swiss albino mice. Material and methods: Hyperglycemia was induced in mice by single intraperitoneal injection of alloxan (150 mg/kg body weight). Three days after alloxan induction, the hyperglycemic mice were treated with Azadirachta indica orally at the dose of 200 and 400 mg/kg body weight daily for 28 days. Serum biochemical parameters such as serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), billirubin, glucose were estimated. Antioxidant properties were assessed by estimating lipid peroxidation, SOD and catalase (CAT). Results and discussion: Azadirachta indica at the dose of 200 and 400 mg/kg orally significantly (P Azadirachta indica treated mice as compared with alloxan control. Azadirachta indica treatment also significantly (P Azadirachta indica leaf demonstrated remarkable anti-hyperglycemic activity in alloxan-induced diabetic mice. The potential anti-hyperglycemic action is plausibly due to its underlying antioxidant role.