Ranitidine Ban – A Review

摘要

Peptic ulcer are chronic lesions which occur in any parts of gastro intestinal tract and is caused due to excess acid secretion in the stomach. Ranitidine is a H2 (histamine-2) blocker drug, which decreases the amount of acid secretion in the stomach. It is available in different formulation like tablet (150-300mg), capsule(150-300mg) and as parentrals (50-400mg).It is given twice daily and is used to treat intestinal and stomach ulcers and prevent them from coming back after they have healed .The U.S Food And Drug administration has observed that, in some Ranitidine medicines, commonly sold under the brand-name Zantac, found traces of a nitrosoamine impurity called N-Nitrosodimethylamine (NDMA) at lower level and that impurity linked to the development of causing certain Cancers. Due to this defect, Ranitidine was Banned in many Countries including India.