FORMULATION AND EVALUATION OF DILTIAZEM HCl FAST DISSOLVING TABLETS USING DIFFERENT CO-PROCESSED EXCIPIENTS BY DIRECT COMPRESSION METHOD

摘要

The aim of present work was to prepare Diltiazem HCl Fast Dissolving tablets by Direct compression method because of their convenience in administration and suitability for patients having dysphagia using Co-processed excipients-Disintequik MCC25, Disintequik MCC, Lubritose MCC, Lubritose SD, Lubritose AN, NF Fast flow Lactose Monohydrate modified spray dried. The Prepared powdered blend and tablets were evaluated for Pre compression parameters such as Angle of repose, Bulk density, Tapped density, Compressibility index, Hausners ratio and Post compression parameters such as weight variation, thickness, hardness, disintegration time, content uniformity, in-vitro dissolution studies and stability studies. All the parameters were within the limits. IR and DSC study showed that drug and excipients were compatible with each other. Twelve formulations were prepared by direct compression method in which F10 was the best formulation using Disintequik MCC25 at a concentration of 4% as it was disintegrated with in 30 sec and drug release was 99.88% over a period of 15 min. The wetting time and disintegration time decreases considerably with the increase in co-processed excipients.