Heavy Metals Detection of a Carp Species, Barilius bendelisis (family cyprinidae) Collected from the Shnebaye Stream of District Karak, Khyber Pakhtunkhwa Province, Pakistan”

摘要

Medicinal plants with anti-oxidation, anti-inflammation and anti-depression compounds have been administered traditionally in the treatment of some human diseases. Alzheimer’s disease (AD) is one of the most debilitating diseases which have no definite cure. Recently, there is a tremendous surge in demand for natural non-steroidal drugs because of their established safety and efficacy through decades of usage by various cultures. In this study, we focused on designing and synthesis of four novel amino acids salts derivative of 3-O-acetyl-11-keto-beta-boswellic acid (AKBA) and their pharmaceutical effects evaluated by measuring of their acetyl cholinesterase (AChE) inhibitory activity. Therefore, at the first step, acetylation of boswellic acid (BA) using acetic anhydride and pyridine, following oxidation with chromium three oxides led to the formation of AKBA. Then AKBA were coupled with valine (Val), alanine (Ala), leucine (Leu) and isoleucine (Ile) in alkaline conditions of reaction. Experimental data showed that AKBA-Val and AKBA- Leu acted as appropriate inhibitors of AChE. The structure of all products in each step were characterized and confirmed by analytical and spectroscopic methods.