Chemical Stability of Compounded Spironolactone Suspension in Proprietary Oral MixTM Over a 90-day Period at Two Controlled Temperatures in Different Storage Containers”

摘要

Fixed drug eruption (FDE) is a distinctive type of cutaneous drug reaction that characteristically recurs in the same locations upon re exposure to the offending drug. It is responsible for about 10% of all adverse drug reactions. Medications inducing fixed drug eruptions are usually those taken intermittently. Common drugs causing fixed drug eruptions are fluconazole, ciprofloxacin, doxycycline, clarithromycin, NSAIDs, trimethoprim, cotrimoxazole, phenytoin etc. We hereby report a case series of multifocal fixed drug eruption (FDE) with drugs of various groups. The above culprit drugs are widely prescribed in the clinical departments for various infections, painful conditions & in fever. Fixed drug eruption is common in these drugs but multiple fixed drug eruptions are very rare with the use of these suspected drugs and thus, the lesions may be misdiagnosed and mistreated. Based on our findings, which are consistent with a number of other practitioners, we recommend adding multiple fixed drug eruption to the list of possible side effects of the above mentioned drugs.