Taste Masking: A Pathfinder for Bitter Drugsby N. Shet, I. Vaidya, India.Digital copy link 02 lang='PT-BR' style='font-size:12.0pt;font-family:'Calibri','sans-serif';mso-fareast-font-family:'Times New Roman';color:#C00000;mso-ansi-language:PT-BR;mso-fareast-language:EN-US;mso-bidi-language:AR-SA;mso-bidi-font-weight

摘要

Most of the pharmaceuticals are administered by the popular route of drug delivery, the oral route. Taste is an important and critical parameter in administering formulations which come in contact with the taste buds. Many drugs have bitter taste, thus this is one of the important formulation problem encountered. Due to the bitter taste of the drug there is a constant problem in the treatment of the patients due to their inability or unwillingness to swallow such formulation specially, in children and elderly. Thus, masking of unpleasant taste characteristics of drug is an important factor in formulation of these agents. This lead to the development of taste masking technologies which improved the characteristics of the dosage form and good patient compliance is achieved. The present review depicts the various approaches like use of flavorants and sweeteners, coatings, microencapsulation, prodrug, use of lipoproteins, ion exchange resins, inclusion complex formation, salt formation, granulation and by multiple emulsions. It also includes the commercially used technologies and the methods for evaluation of the taste masking effect.