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外文期刊>International Journal of Pharmaceutical Sciences Review and Research
>A VALIDATED HPTLC DETERMINATION OF AN ANGIOTENSIN RECEPTOR BLOCKER OLMESARTAN MEDOXOMIL FROM TABLET DOSAGE FORMby *Della Grace Thomas Parambi, Dr. Sr. Molly Mathew, Dr.V.Ganesan, Anila Jose, Dr. K. G. Revikumar, India. 007
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A VALIDATED HPTLC DETERMINATION OF AN ANGIOTENSIN RECEPTOR BLOCKER OLMESARTAN MEDOXOMIL FROM TABLET DOSAGE FORMby *Della Grace Thomas Parambi, Dr. Sr. Molly Mathew, Dr.V.Ganesan, Anila Jose, Dr. K. G. Revikumar, India. 007
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机译:片剂剂量形式中有效的高效液相色谱法测定血管紧张素受体阻滞剂奥美沙坦MEDOXOMIL,作者:Della Grace Thomas Parambi博士,S。Molly Mathew博士,V.Ganesan博士,Anila Jose博士,K。G. Revikumar博士。 007
The oral delivery of lipophilic drugs presents a major challenge because of the low aqueous solubility of such compounds. Self- microemulsifying drug delivery systems (SMEDDSs) have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs. SMEDDS, which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. SMEDDS can be orally administered in soft or hard gelatin capsules and form fine relatively stable oil-in-water (o/w) emulsions upon aqueous dilution owing to the gentle agitation of the gastrointestinal fluids. The efficiency of oral absorption of the drug compound from the SMEDDS depends on many formulation?related parameters, such as surfactant concentra on, oil/surfactant ra o, polarity of the emulsion, droplet size and charge, all of which in essence determine the self-emulsification ability. Thus, only very specific pharmaceutical excipient combinations will lead to efficient self-microemulsifying systems. Although many studies have been carried out, there are few drug products on the pharmaceutical market formulated as SMEDDS confirming the difficulty of formulating hydrophobic drug compounds into such formulations. Significant improvement in the oral bioavailability of these drug compounds has been demonstrated for each case. The fact that almost 40% of the new drug compounds are hydrophobic in nature implies that studies with SMEDDS will continue, and more drug compounds formulated as SMEDDS will reach the pharmaceutical market in the future.
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