FORMULATION AND IN-VITRO EVALUATION OF METOCLOPRAMIDE HYDROCHLORIDE ORODISPERSIBLE TABLETS

摘要

Recent advances in novel drug delivery aims to enhance the safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance. One such approach is oral disintegrating tablets . Oro-dispersible tablets are a suitable means of drug delivery system for better patient compliance, rapid onset of action, increased bioavailability. The purpose of the present research was to formulate and evaluate the mouth disintegrating tablets of metoclopramide hydrochloride. Metoclopramide hydrochloride was used as the active drug, and superdisintegrants like sodium starch glycolate (SSG), crospovidone (CP) and croscarmellose sodium (CCS) were used in the formulation. A total of 7 formulations were fabricated using a direct compression method. The amount of superdisintegrants was varied in each formulation. All the formulations were subjected to pre and post compression parameters. Preformualtion stability study was done to ensure the drug-excipient compatibility study. The effect of superdisintegrants on wetting time, disintegration time and dissolution profile were evaluated. Among the formulated batches, the formulation containing CP 5% and CCS 5% was the most effective and showed disintegration time of 26 seconds and dissolution of 104.02% in 10 min. The study showed that the superdisintegrants were effective in lowering the disintegration time of orodispersible tablets. The formulations containing CP showed better drug release pattern than the formulations with other superdisintegrants in the formulation of orodispersible tablets of metoclopramide hydrochloride.