Cyclotron production of 89Zr: A potent radionuclide for positron emission tomography

摘要

In the present study, zirconium-89 (T1/2= 3.27 day, Iβ+= 23%, Eβ+= 0.897 MeV) was produced through the89Y(p,n) nuclear reaction at the Agricultural, Medical and Industrial Research School (AMIRS)Cyclotron (Cyclone-30, IBA, Belgium), irradiating Y2O3with 15 MeV proton beam energy and 20 µA current for 20 min. The experimental yield of about 69.77 MBq89Zr per µAh was obtained. The radiochemical separation of89Zr from the irradiated Y2O3target was done through the anion exchange chromatography with an overall of 95% process. The intended use of89Zr is to label monoclonal antibodies (MoAbs) for tumor imaging using positron emission tomography (PET).