Accelerated and enhanced osteointegration of MAO-treated implants: histological and histomorphometric evaluation in a rabbit model

摘要

Microarc oxidation (MAO) has become a promising technique for the surface modification of implants. Therefore, the aims of this study were to further quantitatively and qualitatively evaluate the osteointegration abilities of MAO-treated and smooth surface (SF) implants in vivo and to investigate the areas in which the superiority of MAO-treated implants are displayed. In a rabbit model, a comprehensive histomorphological, osteogenic, mineralizational, and integrative assessment was performed using light microscopy, fluorescence microscopy, confocal laser scanning microscopy, and radiographic analyses. Compared with the SF groups, the MAO-treated groups exhibited more active contact osteogenesis, as well as distant osteogenesis, under fluorescence examination, the mineral apposition rate was found to be greater for all of the MAO-treated implants, and the osteointegration index (OI) value was greater in the MAO-treated groups at different times. In conclusion, the calcium-rich amorphous layer created by MAO provided a better environment for osteointegration, with more active contact osteogenesis, a more rapid mineral apposition rate and greater OI values. Implants: A better basis for building bone A pretreatment procedure that creates a porous, mineral-coated surface on dental implants leads to superior integration into bone. Micro-arc oxidation (MAO) can be used to apply thick coatings enriched in phosphorus and calcium onto titanium implants. Researchers led by Baodong Zhao of The Affiliated Hospital of Qingdao University in China have demonstrated that this complex three-dimensional surface offers a supportive environment for bone growth. Zhao and colleagues examined the integration of MAO-treated titanium implants into the femurs of live rabbits relative to implants with smooth surfaces. After 12 weeks, MAO promoted more active bone formation and mineral deposition, and the researchers observed that bone cells readily penetrated the porous surface of these implants to enable extensive skeletal integration. These results suggest that this procedure might meaningfully improve the outcome of dental procedures in the clinic.