Quercetin is a flavonoid widely distributed in nature. It is rich in foods including fruits, vegetables, leaves and grains. It has been used in medicine to control the capillary fragility and blood breeding. It shows pharmacological activities like anti-oxidant, anti-cancer, anti-viral and anti- inflammatory activities etc. The present study was intended for the optimization of extraction of Quercetin from pine apple peel and its various physicochemical parameters have been studied. For the extraction of Quercetin the optimum results were observed for the effect of different solvents, soaking time, different solvent percentages, effect of pH, different volumes of hexane with methanol as solvent, extraction time with hexane were methanol, 1day, 80% (v/v), 7.0, 1:1 ratio and 1hr respectively. The highest Quercetin concentration for optimized condition was 37μg/ml. Methanol was found to be the best solvent for the extraction of Quercetin from pineapple peel by soxhlet extractor. It was carried out for 90 min and an optimum concentration obtained at 50 min with a concentration of 50μg/ml .This Solvent extraction using soxhlet extractor was conduct to verify the mathematical model proposed in this work. The final form of proposed models were E(t) = At2+Bt+C Where A,B&C are constants,Es=yield extract(μg/ml of quercetin) and t=extraction time(min). The final form of proposed equation is E (t)= -0.018t2+1.591t with R2=0.894.
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