Synthesis, Spectral Characterization of N-benzyl isatin chiff base Cu(II), Co(II) and Ni(II) complexes and their effect on Cancer Cell lines

摘要

The efficient antitumor drugs are ever demanding in the present scenario worldwide. The chemotherapeutic activity of isatin compounds can be achieved by chelation of transition metal ions with these bases and expanding in Nregion of these compounds. In this present study, two series of Cu(II), Co(II) and Ni(II) complexes with N-benzyl isatin and isonicotinohydrazide Schiff base ligand (L1) have been synthesized and characterized by using the modern analytical techniques such as IR, NMR, UV-visible, Mass, CV, and EPR etc. All the complexes are soluble in DMF and DMSO. Elemental analysis and molar conductance values indicate that the complexes are non-electrolytes. All the complexes adopt octahedral geometry around the metal ions. DNA binding activities of the complexes Cu(II), Co(II) and Ni(II) are studied by UV-vis and also cleavage studies of complexes have been done by agarose gel electrophoresis method. Cytotoxicity experiments carried out toward human AGS-gastric cancer cell line. Interestingly, compound, L1- Ni was found to be excellent anticancer activity against AGS-gastric cancer cell line.