Camel Milk Ameliorates Hyperglycemia-Mediated Hyperlipidemia and Oxidative Stress on Streptozotocin-Induced Diabetic Rats

摘要

The present study aimed to assess the hypoglycaemic effects of camel milk (CM) and its efficiency on dyslipidaemia and altered antioxidant defence system in streptozotocin diabetic albino rats. The animals were divided into 2 categories; the pre-treated and the treated groups. RawCM (33 ml/kg b. w.) administered daily by oral cannula for 2 weeks pre and after diabetes induction for pre-treated group and 2 weeks only after diabetes induction for treated group. The current study revealed that camel milk administration in pre-treated and treated groups revealed marked significant amelioration on hyperglycaemia, hypoinsulinaemia, hyperlipidaemia, impaired antioxidant defence mechanisms and modulation of PPAR-γ and GLUT4 genes expression as compared to the untreated diabetic rats. These findings revealed the hypoglycaemic effects of camel milk against STZ-induced diabetes through potentiating insulin secretion, modulating PPARγ and GLUT4 expressions and also by hypolipidaemic, potent antioxidant effects.