MYH7 Gene Mutations in Dilated Cardiomyopathy Patients: About 190 Cases at the Institute of Cardiology, Abidjan

摘要

Cardiomyopathies are one of the main causes of heart failure and dilated cardiomyopathy (DCM) is the most common among them in Africa. Several genetic mutations are involved in the etiology of DCM. Thus, the objective of this study was to look for mutations of the MYH7 gene in patients suffering from DCM through a cross-sectional study. For all patients recruited, we collected the socio-demographic, clinical, therapeutic and radiological data. A tube of venous blood was taken in order to research by sequencing mutations on exons 13, 24 and 31 of the MYH7 gene. The study population included 190 patients. They were predominantly male (72.00%) and their mean age was 55.18 ± 13.83 years. The major personal medical history was high blood pressure (20.00%). A family history of heart disease and sudden death was found in 16.80% and 12.60% of patients, respectively. All patients benefiting from sequencing (n = 32) had at least one mutation in the MYH7 gene, so a prevalence of 100%. A total of 29 mutations were observed, divided into 62.07% missense mutations (n = 18/29), 24.14% silent mutations (n = 7/29), 10.34% deletions (n = 3/29) and 3.45% insertions (n = 1/29). Exon 24 was the most unstable with 21 mutations and some patients had multiple mutations. Mutations in the MYH7 gene were frequent and diverse in patients with DCM in C?te d'Ivoire. It is necessary to establish the link between these mutations and their importance in early management of DCM.