...
首页> 外文期刊>International Journal of Experimental Diabetes Research: Experimental Diabesity Research >Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate
【24h】

Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate

机译:糖尿病患者的有机硝酸盐和硝酸盐抗性:血管功能障碍和氧化应激的作用,重点是四偏磷酸四氮杂环丁烷的抗氧化特性

获取原文
   

获取外文期刊封面封底 >>

       

摘要

Organic nitrates represent a class of drugs which are clinically used for treatment of ischemic symptoms of angina as well as for congestive heart failure based on the idea to overcome the impaired NO bioavailability by “NO“ replacement therapy. The present paper is focused on parallels between diabetes mellitus and nitrate tolerance, and aims to discuss the mechanisms underlying nitrate resistance in the setting of diabetes. Since oxidative stress was identified as an important factor in the development of tolerance to organic nitrates, but also represents a hallmark of diabetic complications, this may represent a common principle for both disorders where therapeutic intervention should start. This paper examines the evidence supporting the hypothesis that pentaerithrityl tetranitrate may represent a nitrate for treatment of ischemia in diabetic patients. This evidence is based on the considerations of parallels between diabetes mellitus and nitrate tolerance as well as on preliminary data from experimental diabetes studies.
机译:有机硝酸盐代表一类药物,其临床思想是通过“ NO”替代疗法克服NO的生物利用度受损的想法,临床上用于治疗心绞痛的缺血性症状以及充血性心力衰竭。本文着重于糖尿病和硝酸盐耐受性之间的相似性,旨在探讨糖尿病患者中硝酸盐抗性的潜在机制。由于氧化应激被认为是对有机硝酸盐耐受性发展的重要因素,但它也代表了糖尿病并发症的发生,因此这可能代表了应该开始治疗干预的两种疾病的共同原则。本文研究了支持以下假设的证据,即四硝酸季戊四醇酯可能代表硝酸盐治疗糖尿病患者的缺血。该证据是基于对糖尿病和硝酸盐耐受性之间的相似性以及实验性糖尿病研究的初步数据的考虑。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号