Electrochemical Methodology for NSAID's Determination and its Interaction with Steroid Dexamethasone

摘要

The new generations of Non-Steroidal Anti-inflammatory Drugs (NSAIDS) are COX-2 selectivecyclooxygenase-2 inhibitors (analgesic and anti-inflammatory) capable to cause adverse gastrointestinalevents due to drug interactions between one or more co-administered medicines. This causes alterationof the efficacy or toxicity of the co-administered drug. This study presents an electrochemical method(CV) evaluation to study the interactions of Naproxen Sodium and Piroxicam with Dexamethasone(Steroid) under optimized conditions. The proposed method is electrochemically diffusion controlled asboth drugs showed different diffusion coefficients (Piroxicam: 2.188×10 -7 ; Naproxen Sodium:3.755×10 -5 ). The method has good reproducibility and validated according to ICH guide lines (R 2 =0.9994 for Naproxen Sodium and 0.9991 for Piroxicam). The interactions were confirmed by the FTIRstudies indicated the variation of wave number and intensity of significant peaks thereby revealedpossible interaction sites.