Electrochemical Detection of Paracetamol Using Graphene Oxide -Modified Glassy Carbon Electrode

摘要

A very sensitive electrochemical sensor has been developed by modification of glassy carbon electrode(GCE) with graphene oxide (GO). The electrochemical behavior of paracetamol was studied atGO/GCE using cyclic voltammetry (CV) and square-wave voltammetric techniques (SWV). A welldefined oxidation peak was observed in 0.1 M KH2PO4 electrolyte solution by solid phasevoltammetry. Under the CV techniques, it appears that the catalytic effect of the modification ongraphene oxide GO/GCE shows higher current response as compared to bare GCE. Observed peakpotential was shifted to less positive value by about 220 mV and current was significantly enhanced byabout 2 folds. Square-wave voltammetry showed higher sensitive response than CV techniques, wherecurrent was significantly enhanced by more than 2 folds. Under the optimum conditions, the oxidation-8 -1 peak current of paracetamol varied linearly with concentration over a wide range of 5 x 10 mol L to-6 -1 -8 1 x10 mol L and the detection limit of this method was as low as 4.9 x 10 M.