Determination of Ondansetron Hydrochloride by a Liquid Membrane Potentiometric Sensor Based on Room Temperature Ionic Liquids

摘要

A new potentiometric sensor is introduced for simple and fast determination of Ondansetronhydrochloride in its formulations. Liquid membrane electrode in connection with Ag-Ag/Cl referenceelectrode was set-up and used for the potentiometric measurements. The membrane of the indicatorelectrode composed of a suitable ion-pair complex, dibutyl phthalate as the solvent mediator, PVC as apolymeric matrix and a room temperature ionic liquid (RTIL). RTIL helps the membrane to plasticizethe media better and extract the drug ions from the aqueous solution to the organic phase of themembrane effectively. Different room temperature ionic liquids were tested. Using room temperatureionic liquids also decrease the Ohmic resistance of the membrane. The proposed sensor can applied in-6 -2 -1 -6 the concentration range of 5.010 -1.010 mol L of Ondansetron with a detection limit of 4.510-1 mol L . The potentiometric measurement can be done in pH range of 3.5 to 5.5. The proposedelectrode displayed fast response time about 18 s and can be used for a period of seven weeks withoutany considerable change in its performance.