Comparative analysis of prophylactic intramuscular 15 PGF2? 125 ?g V/s intravascular methylergometrine for prevention of atonic post-partum haemorrhage (PPH) in high risk cases.

摘要

Objectives: To assess, evaluate and compare the safety and efficacy of intramuscular 15 PGF2? 125 ?g and intravenous 0.2mg methylergometrine during active management of third stage of labour in high risk women who are prone to develop atonic postpartum haemorrhage. Methods: 150 women at high risk factors of developing atonic PPH were divided into two groups. Group A received methylergometrine 0.2 mg intravenously and group B received 125mg PGF2a intramuscularly at the time of delivery of anterior shoulder prophylactically. Duration of third stage of labour, amount of blood loss, side effects of drugs used and complications, if any were noted and analyzed. Results: Amount of blood loss was more in group A as compared to group B. Diarrhoea was seen in 3 cases in prostaglandin group, none in methylergometrine group. Nausea, vomiting were seen in 2 women in each group. Conclusions: Prophylactic intramuscular 15 PGF2? 125 ?g is a better alternative to prophylactic intravenous methylergometrine 0.2 mg in high risk women who are more prone to develop atonic PPH.