SYNTHESIS AND ANTIFUNGAL ACTIVITY OF 6-BROMO-2[(4-(2,3-DICHLOROPHENYL)) PIPERAZINE-1-YL)METHYL]-3-[8-HYDROXY QUINOLINE -5-YL]-3-QUINAZOLIN -4-ONE LIGAND AND ITS TRANSITION METAL CHELATES

摘要

The present investigation involved the synthesis of novel ligand HL14andits chelate complexes with Cu(II), Ni(II), Co(II), Mn (II) and Zn(II). The characterizationstudies of chelates were conducted using various physicochemical methods such aselemental analysis, conductometric studies, magnetic susceptibility, FT-IR, NMR andelectronic spectral data. The stoichiometry of the complex has been carried out and foundto be 1: 2 (Metal: ligand). An octahedral geometry around Co (II), Ni (II) and Mn (II),distorted octahedral geometry around Cu (II) and tetra hedral geometry around Zn(II)have been proposed. The antifungal activity of ligand and its metal chelates wasperformed against various fungi