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Modeling HIV/AIDS co infection with malaria and tuberculosis: the role of treatment and counseling

机译:模拟艾滋病毒/艾滋病与疟疾和结核病的共感染:治疗和咨询的作用

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HIV/AIDS remains one of the leading causes of death in the world with its effects most devastating in Sub Saharan Africa due to its dual infection with opportunistic infections especially malaria and tuberculosis. This study presents a co infection deterministic model defined by a system of ordinary deferential equations for HIV/AIDS, malaria and tuberculosis. The HIV/AIDS only model is analyzed to determine the conditions for the stability of the equilibria points and assess the role of treatment and counseling in con-trolling the spread of the infections. This study shows that effective counseling reduces the value of the reproduction number for HIV/AIDS (R H ) to less than unity eliminating the HIV/AIDS problem. Numerical simulations show that applying anti-retroviral treatment (ARV’S) without effective counseling increases the value of R H , worsening the HIV/AIDS problem, however ARV treatment coupled with effective counseling reduces the value of R H to a level below one eliminating the disease. The study further shows that when the proportion of those receiving ARV treatment without effective counseling increases, the value of R H also increases to a level above one. However effective counseling maintains the value of R H below unity therefore strategies for the control of HIV/AIDS should emphasize counseling and not only treatment.
机译:艾滋病毒/艾滋病仍然是世界上主要的死亡原因之一,由于它是由机会感染引起的双重感染,特别是疟疾和肺结核,其影响在撒哈拉以南非洲最为严重。这项研究提出了一个共同感染确定性模型,该模型由针对HIV / AIDS,疟疾和结核病的普通推导方程组定义。分析仅HIV / AIDS模型,以确定平衡点稳定性的条件,并评估治疗和咨询在控制感染扩散中的作用。这项研究表明,有效的咨询可以将艾滋病毒/艾滋病的繁殖数量的价值降低到小于消除艾滋病毒/艾滋病问题的统一水平。数值模拟表明,在没有有效咨询的情况下进行抗逆转录病毒治疗(ARV'S)会增加R H的值,使HIV / AIDS问题恶化,但是,抗逆转录病毒疗法与有效咨询相结合会使R H的值降低到消除疾病的水平以下。研究还表明,如果在没有有效咨询的情况下接受抗逆转录病毒治疗的人比例增加,R H的值也会增加到高于1的水平。然而,有效的咨询将R H的价值保持在统一以下,因此,控制艾滋病毒/艾滋病的策略应强调咨询,而不仅仅是治疗。

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