FABRICATION AND EVALUATION OF ETHYL CELLULOSE AND CELLULOSE ACETATE COATED CONTROLLED RELEASE MULTIPARTICULATE FORMULATION OF KETOPROFEN BY DRY POWDER LAYERING TECHNOLOGY

摘要

Multiparticulate is one of the most widely accepted technologies in thepharmaceutical industries.Present study aim is to prepare controlled release multiparticulate ofKetoprofen by drug powder layering technology using two different release retardant (EthylCellulose & Cellulose Acetate) in five different drug: release retardant concentrations (5%, 10%,20%, 30% & 40%). The most widely used multiparticulate system in pharmaceutical industries isDry Powder Layering Technique. Powder layering involves the deposition of successive layersof dry powder(s) and excipients on preformed nuclei or cores with the help of binding liquids.The prepared multiparticles were evaluated for friability, drug content uniformity, density andpercentage yield. The release rate was evaluated by dissolution studies. To establish drugpolymer compatibility DSC and FT IR was done. Study concluded that Dry Powder Layering ofKetoprofen can be effectively used for drug loading on non-pareil seeds. It was also found thatformulation having Ethyl Cellulose have more retarding capacity than the Cellulose Acetate inboth formulationsand drug release follows Zero order kinetics. DSC and FT IR study concludedthat there is no interaction between EC and CA.From dissolution parameter of the preparedmultiparticles it is concluded that formulation EC3 (20%) and CA4 (30%) posses the requiredcharacteristics of oral controlled release formulation. It is assumed that above 90% of the drugwill be released within 24 hours. Hence this formulation can be used as once daily dosageregimen for the controlled release of Ketoprofen.