THE EFFECT OF ACETYLSALICYLIC ACID ON HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN FEMALE ALBINO RATS

摘要

The present investigation is aiming at studying the effect of oral administration of aspirin(acetylsalicylic acid, ASA) drug on female albino rat, Rattus rattus norvegicus. The female rats (n=24)were allocated into 2 groups as control and treated. The treated rats (n=12) were given orally with highdose of aspirin at a dose of 100 mg/ kg body weight for 15 days (n=6) and 30 days (n=6). And bodyweight, relative organ weights, hematological parameters such as Hb %, total count RBC and total countWBC; and biochemical estimations in blood serum such as glucose, protein, cholesterol and calcium weremeasured. The aspirin did not showed much significant variations in the body weight, relative organweights, serum protein, serum cholesterol, serum calcium, total counts RBC and Hb %; while, aspirindeclined serum glucose level and elevated total count of WBC. The present investigation indicated thatthe aspirin impairs serum glucose level and total count of WBC by modulating of certain enzymesmetabolism in albino rats