Outcome of patients presenting with acute coronary syndrome with vitamin D deficiency

摘要

Background: Vitamin D deficiency, described as ‘Novel Risk factor’for cardiovascular diseases, has been found to be associated withadverse outcome after acute coronary syndrome (ACS) & cardiacsurgery. With insufficiency of this vitamin reaching above 90% inIndians, it shall be interesting to study its relationship with ACSoutcome.Methods: We studied impact of Vitamin D Deficiency/insufficiencyon MAACE during hospitalization & up to 6 months afterdischarge in patients of ACS admitted to our ICCU. Vitamin Dlevels were estimated (ELISA) in two groups - Gp I included 117patients of ACS and Gp-II- 100 age/sex matched healthy controls.Results: In the study Gp, Vitamin D levels were insufficient/deficient(25-75 nmol/L) in 109 patients (93 %) while this figure inhealthy adults was 88 pts (88%). The mean age of study group was49.4 + 10.9 years &majority was male. Of 117 patients, 22 presentedwith unstable angina and 95 with STEMI. All patients ofSTEMI were thrombolysed. The study gp was divided into Vit Ddeficient and sufficient subgroupsto study the MAACE as shownbelow.Although, MAACE appear to occur more frequently in patientsof ACS, the difference did not reach statistical significance.Conclusions: Vitamin D deficiency tough linked with pathophysiologyof Cardiovascular diseases and some studies showingincreased MAACE in Vitamin D deficient patients, exact cause andeffect relationship still need to be defined in larger studies.Interestingly, 88% healthy controls in this study also had vit-Dinsufficiency.