Vascular stiffness in both men and women with more than 3 risk factors from urban, semi-urban and rural areas of South India

摘要

Background: With increasing acute vascular events involving vitalorgans at premature age in India, a part of South East Asia is amatter of concern since the incidence of ACS, stroke and PVD were15%, 0.2% and 10% respectively.WHO repeatedly emphasize the useof biomarkers, surrogate markers at population level to identify riskfactors and occult disease for appropriate intervention at early stageto prevent increasing mortality andmorbidity to establish quality oflife. The present study is envisaged to assess vascular stiffness ofboth sexes in the age group of 20–60 years with more than 3 riskfactors to know the risk burden in South Indian populationMaterials and methods: Study design: Multistage stratified randomisedcluster sampling. Study setting: Urban (Chennai), semi-urbanand rural areas from Thiruvallur and Kanchipuram districts ofTamil Nadu. Sample size: 8080, both gender, age 20–60 years.Methods: Arterial pressure wave forms were obtained from radialartery, right common carotid artery and right femoral artery byapplanation tonometer using SphygmoCor MM3?. ASP, APP, AAP,AAIx and PWV were recorded as determinants of vascular stiffness.Results: Among the recruited 8080 study participants, 44.9% weremales and 55.1% were female and 2221, 2821 and 3038 were fromurban, semi-urban and rural regions respectively. Using 2 sampledtest of proportion the following statistical significance is observedbetween urban and rural population.