首页> 外文期刊>Indian journal of dermatology >Demographic characteristics and association of serum Vitamin B12, ferritin and thyroid function with premature canities in Indian patients from an urban skin clinic of North India: A retrospective analysis of 71 cases
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Demographic characteristics and association of serum Vitamin B12, ferritin and thyroid function with premature canities in Indian patients from an urban skin clinic of North India: A retrospective analysis of 71 cases

机译:印度北部城市皮肤诊所印度裔患者的人口统计学特征及其血清维生素B12,铁蛋白和甲状腺功能与早产的关系:回顾性分析71例

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Background: The incidence of self-reported premature hair graying (PHG) seems to be on the rise. PHG has a profound impact on the patient's quality of life. It remains an incompletely understood etiology with limited and modest treatment options. Aim: The evaluation of the demographic and clinical profile of patients with premature canities, and exploration of the association of this entity with certain systemic disorders suspected to be related to its etiology. Methods: Seventy-one cases of premature canities (onset noticed by patients before 25 years of age) presenting to an urban skin clinic in Gurugram, India, between September 2012 and September 2015 with this complaint were retrospectively analyzed. The patient records were retrieved that provided details of the onset, duration and pattern of involvement, history, and examination findings (scalp, cutis, and general physical). Since all these patients had been screened for anemia, thyroid disorder, fasting blood glucose, and Vitamin B12 levels at the time of presentation, these parameters were also available for analysis. Results: The mean age at onset of graying was 10.2 ± 3.6 years (range: 5–19 years), with an almost equal gender distribution. The earliest age of onset recorded was 5 years. A positive family history of PHG (at least one of the biological parents or siblings) was obtained in 64 (90.1%) of the cases. The temporal regions of the scalp (35.2%) were most commonly involved followed by the frontal region (18.3%). Hypovitaminosis B12 and hypothyroidism showed significant association with the disorder, whereas anemia, serum ferritin, and fasting blood glucose did not. Conclusion: The age of onset of hair graying can be as low as 5 years. Temporal and frontal areas are the most commonly involved sites. A strong family history, Vitamin B12 deficiency, and hypothyroidism are strongly associated with PHG. Larger case–control studies are mandated for discerning the correlation of these and other risk factors with PHG.
机译:背景:自我报告的过早白发(PHG)的发病率似乎正在上升。 PHG对患者的生活质量产生深远影响。它仍然是病因不完全了解,治疗方案有限且适度。目的:评估早产儿的人口统计学和临床​​特征,并探索该实体与某些可能与其病因有关的系统性疾病的关联。方法:回顾性分析2012年9月至2015年9月间在印度古尔格拉姆市一家皮肤诊所就诊的71例早产儿(25岁之前的患者注意到的发病)并进行了投诉。检索患者记录,以提供发作的详细信息,持续时间和受累方式,病史和检查结果(头皮,皮肤和一般身体状况)。由于在就诊时已对所有这些患者进行了贫血,甲状腺疾病,空腹血糖和维生素B12水平的筛查,因此这些参数也可用于分析。结果:灰白发作的平均年龄为10.2±3.6岁(范围:5-19岁),性别分布几乎相等。记录的最早发病年龄是5岁。在64例(90.1%)病例中获得了PHG阳性家族史(至少有一个亲生父母或兄弟姐妹)。头皮的颞部区域(35.2%)是最常见的,其次是额叶区域(18.3%)。低维生素B12和甲状腺功能低下与该疾病显着相关,而贫血,血清铁蛋白和空腹血糖则无相关性。结论:头发变白的发病年龄可低至5岁。颞叶和额叶区域是最常见的场所。家族史丰富,维生素B12缺乏和甲状腺功能低下与PHG密切相关。要求进行更大的病例对照研究,以识别这些及其他危险因素与PHG的相关性。

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