“D-cell hypothesis of schizophrenia” indicates mechanisms of progressive pathology of schizopnrenia

摘要

Specifically, genes downregulated in DLG2 KO cells during the transition from NPCs to immature neurons were highly enriched for schizophrenia common variant association. Further analysis revealed this enrichment to be greatest amongst genes underlying active neuronal properties (e.g. action potential gen- eration and voltage-gated sodium channel activity). This study unveils a novel role for DLG2 in cortical development, shedding light on neurodevelopmental processes contributing to schizophrenia pathophysiology.