Abnormal activation of NMDA receptors by Glufosinate ammonium

摘要

However, the underlying mechanism about JEV triggers neuronal cell apopto- sis remains unclear. The objective of this study was to investigate the JEV infection of human neuroblastoma SH-SY5Y cells including virus replication and virus-induced neuronal cell death. The result demonstrated that the virus replicated in time-dependent pattern and the progressive of JEV replication was related to the induction of cell death which obviously presented at the late period of infec- tion. Interestingly, the expression levels of the p18 Bax, the cleaved form of Bax, was markedly increased whereas the full-length Bax expression was gradually decreased which corresponded to the increase of neuronal cell death during JEV infection. The formation of truncated p18 Bax appeared to be associated with JEV-triggered neuronal cell death. This novel finding provides another possible mechanism of JEV-induced apoptosis which could lead to further therapeutic developments for alleviating the neuronal injury from the infection of JEV.