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首页> 外文期刊>Arquivos de Neuro-Psiquiatria >Envolvimento do receptor de adenosina A1 na inibi??o da ativa??o de astrócitos mediada por eletroacupuntura durante a dor neuropática
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Envolvimento do receptor de adenosina A1 na inibi??o da ativa??o de astrócitos mediada por eletroacupuntura durante a dor neuropática

机译:腺苷A1受体参与神经性疼痛中电针介导的星形胶质细胞活化的抑制作用

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摘要

Neuropathic pain is a chronic pain condition caused by damage or dysfunction of the central or peripheral nervous system. Electroacupuncture (EA) has an antinociceptive effect on neuropathic pain, which is partially due to inhibiting astrocyte activation in the spinal cord. We found that an intrathecal injection of 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective adenosine A1 receptor antagonist, reversed the antinociceptive effects of EA in a chronic constriction injury-induced neuropathic pain model. The expression of GFAP in L4-L6 spinal cord was significantly upgraded, while DPCPX suppressed the effect of the EA-mediating inhibition of astrocyte activation, as well as wiping out the EA-induced suppression of cytokine content (TNF-α). These results indicated that the adenosine A1 receptor is involved in EA actions during neuropathic pain through suppressing astrocyte activation as well as TNF-α upregulation of EA, giving enlightenment to the mechanisms of acupuncture analgesia and development of therapeutic targets for neuropathic pain.
机译:神经性疼痛是由中枢或周围神经系统受损或功能障碍引起的慢性疼痛。电针(EA)对神经性疼痛有镇痛作用,其部分原因是抑制了脊髓中星形胶质细胞的活化。我们发现鞘内注射8-环戊基-1,3-二丙基黄嘌呤(DPCPX),一种选择性的腺苷A1受体拮抗剂,在慢性收缩性损伤引起的神经性疼痛模型中逆转了EA的镇痛作用。 L4-L6脊髓中GFAP的表达显着提高,而DPCPX抑制了EA介导的星形胶质细胞激活抑制作用,并消除了EA诱导的细胞因子含量(TNF-α)抑制。这些结果表明,腺苷A1受体通过抑制星形胶质细胞活化以及TNF-α上调EA而参与神经性疼痛中的EA动作,对针刺镇痛的机理和神经性疼痛治疗靶标的开发具有启发性。

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