EFFECT OF PANCHAGAVYA GHRITA ON SOME NEUROLOGICAL PARAMETERS IN ALBINO RATS

摘要

Introduction: Sushrut samhita, an authentic ayurvedic text mentions the use of Panchagavya Ghrita (PG) in the treatment of mania, epilepsy, fever and hepatitis. In an effort to correlate the ancient knowledge with the modern concepts of research in the pharmacology, we decided to study the effects of Panchagavya Ghrita on some neuropharmacological parameters including anticonvulsant activity in rats. Material and methods: For all the experiments, the animals were divided into four groups of 10 rats each. First three groups received Panchagavya Ghrita in the dose of 1(PG1), 2 (PG2), 4 (PG4) ml per Kg of body weight respectively and the fourth group received normal saline 2 ml per Kg orally twice daily (9am-9pm) for 30 days 1. Effect on general behavior: 2.Maximal electroshock induced convulsions: After screening convulsions were induced by maximal electroshock method. A current of 150 mA was delivered for 0.2 sec using Techno convulsiometer.3. Spontaneous motor activity (SMA): animals were screened for SMA using Actophotometer. Animals were allowed to adjust to the test chamber of the instrument for 30 minutes and then activity was counted using the digital counter for 5 minutes.4.Pentobarbitone induced sleep time:. Test and control animals both were injected with injection Pentobarbitone in the dose of 45-mg/Kg body weight. The animals were observed for loss and recovery of righting reflex for the calculation of duration of sleep Results: 1) PG protected rats from maximal electroshock induced convulsions 2) increased the spontaneous motor activity as measured by Actophotometer. 3) Inhibited the pentobarbitone induced sleep time in rats. There was no effect on the general behavioral profile of the rats except that there was increase in the locomotor activity in the cages. Conclusion: PG appears to be possessing anticonvulsant properties but the degree of protection is not sufficient to use it as single antiepileptic agent. This action of PG appears to be not mediated through GABA receptors.