COMPARATIVE STUDY OF ALCOHOLIC AND AQUEOUS EXTRACTS OF SYZYGIUM CUMINI ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN WISTAR RATS

摘要

ABSTRACT Objective: In this investigation, the comparative hepatoprotective effect of aqueous and ethanolic extracts of Syzygium cumini (AESC and EESC, respectively) was studied on carbon tetrachloride (CCl )-induced hepatic injury in rats. These findings were also compared with the standard hepatoprotective drug silymarin. Methods: Hepatotoxicity was induced by a single dose of CCl 4 to healthy Wistar rats. Standard drug (100 mg/kg) and test extracts (500 mg/kg for both) were given orally for 10 days; the effects were observed using different biochemical and histological methods. 4 Results: In most of the studied parameters test extracts exhibited significant hepatoprotection, these were comparative to standard. Histological analysis also revealed the protective nature of both the extracts. Conclusion: These results suggest that the SC extracts can ameliorate CCl induced hepatic injury. However, its ethanolic extract was found to be relatively less effective than aqueous extract. Indicated, some hydrophilic active compound of SC might work here. 4 Keywords: Hepatoprotective, Carbon tetrachloride, Silymarin, Syzygium cumini, Alkaline phosphatase, Total bilirubin.