Toxic and essential metals in placenta and its relation with lipid peroxides/glutathione status in pre-term and full-term deliveries

摘要

Aims and Objectives: Pre-term birth is worldwide problem, little is known about oxidative stress in placental tissue due to metals exposure of women during pregnancy. To seek correlation between concentration of metals and redox status in placental tissue of women with pre-term delivery and compared with those of women with the full-term delivery. Materials and Methods: A hospital based case–control study was conducted, total 80 pregnant women were selected for this study i.e., 30 females who delivered pre-term babies (gestational age 37 week) serve as control group. Concentrations of metals lead (Pb), cadmium (Cd), iron (Fe), zinc (Zn), and (Cu), malondialdehyde (MDA) end product of lipid peroxidation and glutathione (GSH) were measured in placenta of study group and control group. Data were analyzed using Students t- test, chi square and linear regression. Results: In preterm cases level of malondialdehyde (MDA) and metals (Cd and Pb) were significantly higher, while level of GSH and some metals (Fe, Zn and Cu) were significantly lower in pre-term cases when compared to full-term cases. There were significant positive correlations of placental metals (Pb and Cd) with MDA (p<0.05), suggests that metals might have influenced pre-term deliveries. Conclusions: The results showed that elevated level of placental Cd and Pb induced oxidative stress which might implicate in pre-term deliveries and higher concentration of Zn and Cu may be concerned with the defence against oxidative stress in placental tissue of full-term cases. Asian Journal of Medical Sciences Vol.7(1) 2015 34-39