Risk Factors, Biomarkers, Etiology, Outcome and Prognosis of Ischemic Stroke in Cancer Patients

摘要

Introduction: Cerebrovascular disease is the second most common complication in individuals with tumours.The aim of this study was to investigate risk factors, biomarkers, etiology and prognosis of ischemic stroke in cancerpatients (ISCPs). Methods: The medical records of 619 consecutive patients who were admitted with acute ischemicstroke from January 2012 to November 2014 were retrospectively evaluated. The patients were divided into two groups(group 1, patients with an active cancer prior to the onset of ischemic stroke; group 2, patients without an active cancerhistory). The demographic data, risk factors, NIHSS scores, thrombocyte count, D-dimer, fibrinogen and C reactiveprotein (CRP) level at admission, modified Rankin Scale (mRS) scores in the follow-up period and location of lesionson DWI were recorded. The Mann-Whitney U test, chi-squared test and logistic regression was used for analyzing data,pwas significantly lower in the ISCP group (p=0.001). Elevated thrombocyte counts, D-dimer, fibrinogen and CRP levelsat admission, acute multiple ischemic lesions, other causes, mortality in hospital and worse outcome were significantlyrelated to ISCP (p 3, acute multiple ischemic lesions locatedin more than one vascular territory (AMIMCT) and other causes were significantly associated with ISCP (p 3 were more common in the ISCP group. We consider thatCCS could be more suitable for detecting other causes than TOAST. Biomarkers could be important in the ISCP group.