Utility of untimed single urine protein/creatinine ratio as a substitute for 24-h proteinuria for assessment of proteinuria in systemic lupus erythematosus

摘要

Introduction In this study, we determined: (1) the utility of an untimed?sample of urine protein/creatinine?ratio (PCR) as a screening test for proteinuria, (2) its ability to accurately measure proteinuria, and (3) cutoff values for PCR predicting protein content in a 24-h urine collection sample (24hP) of 0.5, 1.0, and 2.0?g/day. Methods Analysis was performed on data from a single lupus cohort (2008–2014). Proteinuria was measured in a 24hP and with PCR. On the basis of 24hP, samples were divided?into 4 groups: group 1, Results The correlation of the samples with normal PCR as well as 24hP (n?=?552) was 0.29 (p? Conclusions PCR can be used as a screening test for proteinuria, and the best cutoff value to predict a 24hP of 0.5?g/day is 0.08?g/mmol (800?mg/g). The accurate level of proteinuria should be measured by the gold standard test, 24hP.