Polymorphism of FUT1 Gene M307 and its Relationship with Partial Immune Indexes and Economic Traits in Yorkshire Pigs

摘要

To assess the feasibility of FUT1 gene M307 as a disease resistance genetic marker in Yorkshire pigs, this experiment adopted PCR-RFLP method to investigate the genetic variation s at M307 of FUT1 gene in purebred Yorkshire (total 218 individuals), determined partial biochemical parameters and important cytokines using the automatic blood cell analyzer and ProCarta immunoassay kits and assayed a number of economic traits including eye muscle thickness, backfat thickness, growth rate and reproductive performance . This study also analyzed the relationship between polymorphism of FUT1 gene M307 and partial immune indexes, vital economic traits. The results showed that there were three genotypes (AA, AG and GG) in Yorkshire test groups, in which the allele G was dominant one. FUT1 gene M307 deviated from Hardy-Weinberg equilibrium (p0.05). The individuals with GG genotype were significantly higher than those with AG genotype (pAG>GG, individuals with AA type were significantly higher than those individuals with GG type (p<0.05) in TNB and NBA at 3rd and 5th parities. These results indicated that AA genotype, as an ETEC F18 resistance genetype, would also improve growth rate and reproduction performance of Yorkshire pigs, but reduce their general disease resistance ability.