Optimization of Agsub xmlns:mml='http://www.w3.org/1998/Math/MathML' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xmlns:oasis='http://docs.oasis-open.orgs/oasis-exchange/table'2/subO nanostructures with strontium for biological and therapeutic potential

摘要

Pristine- and strontium-doped Ag2O nanoparticles (NPs) were synthesized utilizing the symbolic co-precipitation method, in which sodium hydroxide was used as a precipitating agent. Various instrumentation methods were employed to get an inside view of the synthesized NPs. Powdered X-ray diffraction (PXRD) analysis revealed the existence of high crystallinity and small-sized NPs (an average diameter range of 35–48?nm). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) displayed spherical and circular disc-shaped morphology of the particles. Energy-dispersive X-ray spectroscopy (EDX) showed the purity of NPs. All the screened metal functionalized Ag2O NPs exhibited excellent cytotoxicity and antibacterial activities, moderate to good antioxidant and antifungal activities in comparison to Ag2O NPs. Furthermore, nanomaterials were evaluated for DNA interaction studies. The results illustrated that by increasing the concentration of dopant, i.e. strontium up to 5%, the binding affinity of the NPs effectively increased, hence causing the structural changes in DNA.