Potential Anti-plasmodial Activity of Synthesized Silver Nanoparticle using Andrographis paniculata Nees (Acanthaceae)

摘要

The synthesis of metal nanoparticles using biological systems is an expanding research area due to the potential applications in nanomedicines. Nanoparticles synthesized by chemical method are not eco-friendly. The biological synthesis of silver nanoparticles is convenient and extracellular method which is environmentally safe. In the present study the silver nanoparticles were successfully synthesized from AgNO3 through a simple green route using the leaves of Andrographis paniculata as reducing as well as capping agent. The obtained nanoparticles were characterized using UV-vis (UV-visible spectroscopy), XRD (X-ray diffraction analysis), and SEM (Scanning electron microscope). X-ray diffraction and SEM analysis showed the average particle size of 35-55 nm as well as revealed their cubic structure. The antiplasmodial activity of these nanoparticles was studies against Plasmodium falciparum. The parasitic property was analyzed by (IC50) values were 26±0.2% at 25 μg/ml, 83±0.5% at 100 μg/ml. The important outcome of the study will be the development of value added products from medicinal plants of india for biomedical and nanotechnology based industries.