Carotid intima-media thickness, 25-OH vitamin D, homocysteine and subclinical coronary artery atherosclerosis in patients with type 1 diabetes mellitus

摘要

Paper description:The predictive significance of elevated plasma total homocysteine, lower serum 25-hydroxy vitamin D and increased carotid intima-media thickness for development of coronary atherosclerosis in patients with type 1 diabetes and no previous history of ischemic heart disease was evaluated.This cross-sectional study included 73 diabetic patients, duration of diabetes over 5 years, age 19-40 years, with and without non-obstructive coronary artery stenosis.Hyperhomocysteinemia, lower serum vitamin D and increased carotid intima-media thickness present a higher risk of developing atherosclerosis.Homocysteine concentration is a reliable predictor for the development of coronary artery atherosclerosis in asymptomatic patients with type 1 diabetes.