Evaluation of a Hydrophilic Ionic Liquid as a Salting-out Phase Separation Agent to a Water–Tetrahydrofuran Homogeneous System for Aqueous Biphasic Extraction Separation

摘要

The use of a hydrophilic ionic liquid (IL), 1-butyl-3-methylimidazolium chloride (C_(4)mimCl), as a salting-out phase separation agent to a water–tetrahydrofuran homogeneous system was studied for possible applications to novel aqueous biphasic extraction separation. The IL showed a salting-out phase-separation ability. Also, differences in the polarity between the formed two phases were smaller than that when using NaCl as a salting-out agent. This result suggested that C_(4)mimCl remaining in water-rich phase acts not only as a salting-out agent, but also a component of a mixed-solvent. Possible uses of C_(4)mimCl/NaCl mixed salting-out agent system were also discussed.