Comparison of inhalant Fluticasone and Beclomethasone in treating mild and moderate persistent asthma in children

摘要

Asthma is one of the most common diseases of childhood ages. Different medications are used in periods between asthma attacks that their principles are inhalant corticosteroids such as beclomethasone and fluticasone. using fluticasone alone, can cause diminish in asthma symptoms in children and also decrease treatment failures resulting from using medicines such as beclomethasone and also reduces the corticosteroid therapy complications. So we decided to preform a research to compare the effectiveness of beclomethasone and fluticasone. This study is a retrospective clinical trial on asthmatic patients refer to Tabriz Alinasab hospital from 2008 to 2010. All patients with mild and moderate persistent asthma were included by their physical examination and medical records at first visit and, if necessary, peak flowmetry and spirometry was done specially in patients elder than eight and with more compliance. Follow ups were done by recording the outcomes at weekly visits and writing down questionnaires according to parents’ opinions about patients condition and satisfaction. There was not a meaningful relationship between age (p=0.393), sex (p=1) and studied groups (p=0.15). There was a meaningful relationship between asthma and response to medication, and also asthma stages (mild or moderate) and kind of used medications. In patients with persistent mild asthma co medication with both beclomethasone and fluticasone was without any failure, but in moderate persistent asthma with single medication therapy, fluticasone had less failure than beclomethasone, and in co medication, salmeterol with fluticasone had no failures but with beclomethasone, some failures reported. Medication with fluticasone in mild persistent asthma and along with salmeterol in moderate persistent asthma is more effective in patient's response to medication and reducing complications.