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Optimum Drug Combinations for the Sedation of Growing Boars Prior to Castration

机译:Cast割前生长公猪镇静的最佳药物组合

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Juvenile male pigs were sedated for castration. Eight five-month old boars were sedated twice (two weeks apart) with a combination of detomidine (0.1 mg/kg), midazolam (0.2 mg/kg) and either butorphanol (0.2 mg/kg) (Group MDB, n = 8) or morphine (0.2 mg/kg) (Group MDM, n = 8) intramuscularly. The boars were positioned in lateral recumbency and lidocaine (200 mg total) was injected into the testicle and scrotal skin. Castration of a single testicle was performed on two occasions. Sedation and reaction (to positioning and surgery) scores, pulse rate, respiratory rate, haemoglobin oxygen saturation, body temperature, arterial blood gas parameters and the times to immobility and then recovery were recorded. Atipamezole was administered if spontaneous recovery was not evident within 60 min of sedative administration. Data were compared with either a paired-sample t -test or a Wilcoxon-Signed Rank Test. There was no difference in sedation score, body temperature, respiratory rate and haemoglobin oxygen saturation between MDB and MDM. Mild hypoxaemia was noted in both groups. There was less reaction to castration after MDB. The pulse rate was higher after MDM sedation. The times to immobility and then recovery were similar. The combination of MDB provided more reliable sedation than MDM. MDB may be useful for sedation for short procedures in pigs, though oxygen supplementation is recommended to avoid hypoxaemia.
机译:将幼小雄性猪镇静以去势。将八只五个月大的公猪用地托米定(0.1 mg / kg),咪达唑仑(0.2 mg / kg)和任一个布托啡诺(0.2 mg / kg)组合镇静两次(相隔两周)(MDB组,n = 8)或肌注吗啡(0.2 mg / kg)(MDM组,n = 8)。将公猪侧卧,将利多卡因(总计200毫克)注射到睾丸和阴囊皮肤中。两次进行割术。记录镇静和反应(对定位和手术的影响)得分,脉搏频率,呼吸频率,血红蛋白氧饱和度,体温,动脉血气参数以及不动和恢复的时间。如果在镇静剂给药后60分钟内未发现自发恢复,则给予阿替米唑。将数据与配对样本t检验或Wilcoxon签署秩检验进行比较。 MDB和MDM之间的镇静分数,体温,呼吸频率和血红蛋白氧饱和度无差异。两组均发现轻度低氧血症。 MDB后对去势的反应较少。 MDM镇静后,脉搏频率更高。固定时间然后恢复的时间相似。 MDB的组合提供了比MDM更可靠的镇静作用。尽管建议使用氧气补充以避免低氧血症,但MDB可能对短期手术中的镇静剂有用。

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