Relationship between pretreatment FDG-PET and diffusion-weighted MRI biomarkers in diffuse large B-cell lymphoma

摘要

The purpose of this study was to determine the correlation between the sup18/supF-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) standardized uptake value (SUV) and the diffusion-weighted magnetic resonance imaging (MRI) apparent diffusion coefficient (ADC) in newly diagnosed diffuse large B-cell lymphoma (DLBCL). Pretreatment FDG-PET and diffusion-weighted MRI of 21 patients with histologically proven DLBCL were prospectively analyzed. In each patient, maximum, mean and peak standardized uptake value (SUV) was measured in the lesion with visually highest FDG uptake and in the largest lesion. Mean ADC (ADCsubmean/sub, calculated with b-values of 0 and 1000 s/mmsup2/sup) was measured in the same lesions. Correlations between FDG-PET metrics (SUVsubmax/sub, SUVsubmean/sub, SUVsubpeak/sub) and ADCsubmean/sub were assessed using Pearson’s correlation coefficients. In the lesions with visually highest FDG uptake, no significant correlations were found between the SUVsubmax/sub, SUVsubmean/sub, SUVsubpeak/sub and the ADCsubmean/sub (emP/em=0.498, emP/em=0.609 and emP/em=0.595, respectively). In the largest lesions, there were no significant correlations either between the SUVsubmax/sub, SUVsubmean/sub, SUVsubpeak/sub and the ADCsubmean/sub (emP/em=0.992, emP/em=0.843 and emP/em=0.894, respectively). The results of this study indicate that the glycolytic rate as measured by FDG-PET and changes in water compartmentalization and water diffusion as measured by the ADC are independent biological phenomena in newly diagnosed DLBCL. Further studies are warranted to assess the complementary roles of these different imaging biomarkers in the evaluation and follow-up of DLBCL.