Potentials of nutritional therapy, phytopharmaceuticals and phytomedicine in the prevention and control of Ebola virus in Africa

摘要

With more than 15000 people infected with Ebola Virus Disease (EVD) leading to more than 7000 deaths in Liberia, Serra Leone, Guinea, Nigeria and Senegal, Ebola Virus Disease remains one of the most dreaded scourges and concerns in contemporary international health (CIH). We note in this essay, that current intervention strategies for the containment of emerging infectious diseases such as Ebola may remain inadequate unless an integrated health intervention (IHI) strategy is adopted. Focus on vaccine development is, undoubtedly, critical but unlikely soon. Synthetic antiviral therapy (AVT) or antifiloviral therapy (AFT) such as using Zmapp, Favipiravir and Brincindofovir amongst others may remain therapeutically inadequate to contain not only Ebola but future scourges. For one fact, as already observed, Zmapp, TKM-Ebola and Favipiravir are hopeful but clouded with toxicity concerns and like any antibiotic of single molecular base likely to be resisted by the bug over time. In this article, our position is that, the medical approach to confront Ebola should be a multidisciplinary approach with equality. This will mean providing a medical care that protects health care workers, searching for an effective vaccine and antiviral therapy that is cost effective, weaving cultural, environmental and community based approaches to preventing the spread as well as fostering and incorporating nutritional therapy, traditional medicine as an integrative package for infectious diseases control. We attempted to highlight that african nutriceticals and phytomedicine could be useful in the control of infectious diseases such as Ebola through the use of medicinal plants such as Garcinia kola extracts and the exploitation of mushroom extracts such as Ganoderma lucidum containing selenium, Iron, zinc, 7-8% crude protein, 26-28% carbohydrates and a range of bioactive protein that can boost the immune system of patients with Ebola virus hemorrhagic fevers. Evidence in grey literature demonstrates profound antiviral activities from extracts of Garcinia kola on a range viruses including Ebola virus. Kolaviron, a class of flavonoids from garcinia kola, have been found with profound antiviral activity while compounds from cordycep mycelium such as beta glucans also reported in Ganoderma lucidum and some mushroom species have profound immune boosting potentials against many viral infections. A computerized data base for these compounds for drug development could be generated for use by pharmaceutical companies. It is concluded that, nutritional therapy, phytopharmaceuticals from medicinal plants, could be used not only as drug leads but could clinically complement current management of Ebola virus diseases in African hospitals.